Evaluation of CO2 Fixation by Microbial Metabolism
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Simultaneous positive and negative HRAM acquisition using a Q-TOF mass spectrometer with ultra-high mass stability
To enable simultaneous positive and negative ion mode MS acquisition on a Q-TOF system, we developed a novel conversion equation for calculating m/z from the measured TOF that compensates for the high-voltage instability after polarity switching. By applying this algorithm to Shimadzu LCMS-9050, it was demonstrated that 600 msec polarity switching time was sufficient for simultaneously achieving low-ppm mass accuracies in both positive and negative modes.
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Analysis for Voriconazole Using Fully Automated Sample Preparation LC-MS/MS System and Comparison of Measurement Methods
Shimadzu participated in the 2020 TDM (therapeutic drug monitoring) Control Survey for Anti-infective Drugs organized by the Japanese Society of TDM Quality Control. Shimadzu used a stable isotope-labeled reagent and LC-MS/MS system with a fully automated sample preparation module for its participation.
