Throughput

What is true high throughput? True high throughput is defined as the total cycle time, which includes not only the data collection time but all the time involved in analysis-sample injection, column equilibration, and autosampler rinsing, and can even include system downtime etc.

Realize True High Throughput

To achieve true high throughput, each Nexera component has undergone core improvements. The Nexera autosampler not only features the world’s fastest sample injection but now also includes the function of overlapping injection as standard, low-volume (20µL) efficient mixer and optional loop injection method configuration to absolutely minimize delay volume.

New SIL-30AC
New SIL-30AC

Realize Ultra-High Resolution

Nexera achieves a perfect balance between the highest resolution and highest speed. Ultra-high pressure (up to 130 MPa) fluidic modules can utilize all the high-resolution column. Nexera facilitates the use of long small-particle columns to analyze trace-level compounds in complex samples.

Ultra-High Resolution with Ultra-High Speed

Highest resolution in a very short interval is accomplished by Nexera’s ultra-high pressure resistance for a broad flow range and the world’s fastest sample injector.

Finest Reproducibility under Ultra-High Speed

High-throughput analysis requires excellent separation and retention time reproducibility.
A new mixer (MiRC), conceived from study of micro reactor technologies, delivers efficient, low-volume mixing for even the most difficult analysis, such as those using TFA, thereby minimizing gradient delay. A micro volume pre-heater as well as the overall system configuration further enhances the reduction of delay volume. Moreover, the LC-30AD pump features an automatic pulsation-correction mechanism and a high-speed parallel micro plunger design to provide pulse-free solvent delivery and excellent retention time reproducibility – even in ultra-high speed gradient conditions.

Computer modeling of mixing process

Reducing the Total Analysis Time

The Prominence UFLC (ultra fast LC) autosampler allows for rapid injection (10 sec).
The Nexera builds upon this technology, providing the fastest injection speed with its reliable XYZ mechanics.
In addition, the Nexera overlapping injection further reduces the total analysis time for the utmost in high throughput.


Further Minimizes System Delay-Volume with Optional Loop Injection Method

The SIL-30AC autosampler can be re-configured to provide the absolute lowest system delay volume by conversion to a loop injector.
This configuration is simple and requires only changing a few plumbing connections.

Large Sample Capacity for High Throughput Sample Analysis

Thousands of analyses per day are not unusual in today’s laboratory. In such demanding laboratories, the maximum sample number for the unattended operation is as important as the analysis speed. The Nexera Rack Changer Ⅱ accommodates up to 12 sample plates (96well, 384well, vial plates) to allow up to 4608 samples to be continuously analyzed unattended.
The Rack Changer Ⅱ incorporates fine temperature control with a cooling function (4 to 40 ºC) to minimize sample degradation during the process.

New Rack Changer Ⅱ
New Rack Changer Ⅱ